print small

Participating Countries:

Algeria

Argentina

Australia

Austria

Belgium

Bosnia and Herzegovina

Bulgaria

Croatia

Czech Republic

Denmark

Finland

France

FYR of Macedonia

Germany

Greece

Iceland

Ireland

Israel

Italy

Lithuania

Morocco

Netherlands

New Zealand

Poland

Portugal

Romania

Russian Federation

Serbia

Slovenia

Spain

Sweden

Switzerland

Turkey

Ukraine

United Kingdom

United States

Member area provided by LTFE
COST is supported by the EU RTD Framework Programme
ESF provides the COST Office through a European Commission contract
This website is supported by COST

Institute of Pharmacology and Structural Biology, CNRS and University of Toulouse

Tell your friend  | 

205, route de Narbonne
31077 Toulouse
France

Contact email:

Visit the website.

Brief presentation of the institution

The Cellular Biophysics group of the IPBS has been founded in 1983 by the Dr Justin Teissié. The group belongs to the Department of Biophysics and Structural Biology of the Institute of Pharmacology and Structural Biology, a mixed laboratory between the CNRS (Centre National de la Recherche Scientifique) and the University of Toulouse, the 4th city of France. 100 permanent research scientifists, 60 administrative and technical staff and 100 non-permanent : graduate students, postdoctoral fellows, undergraduate students (master) work at the IPBS. The members of the Cellular Biophysics group - a multidisciplinary group of biologists, biochemists, biophysists - are involved in research and education (undergraduate and graduate). The aims of the research performed in the group are to elucidate the membrane perturbations mechanisms induced by transmembrane potential changes and to develop new tools for delivery, targeting and diagnostic.

Main Electroporation related topics

Major directions pursued in our group are the elucidation of the mechanisms involved in cell membrane permeabilization (molecule uptake or release) and fusion as well as their applications in biology, biotechnology and medecine, particularly electrochemotherapy (ECT) and gene electrotransfer (EGT). Our strategy is to elucidate these processes at the single cell level by using different models with increasing complexities (Giant vesicles, cells in 2D and 3D culture, small animal) and to visualize them by using different fluorescence imaging tools.

Our group is a member of the EBAM and the Bioelectrics consortium.

Main Electroporation related research techniques and equipment

  • 12 Pulse generators: Jouan, Cliniporator, Betatech...
  • 3 inverted fluorescence microscopes equipped with different sensitive and fast camera (CDD, scMOS camera)
  • 2 light microscopes
  • 2 stereomicroscopes
  • fast kinetic imaging system
  • cell culture room
  • 4 laboratories for experiments on liposomes, bacteria, mammalian cells and small animals

Research topics, techniques and equipment not related to Electroporation

Part of research is dedicated to:

- develop, select, produce and test DNA aptamers that can be used to recognize relevant targets both in vitro and in vivo using SELEX or non-SELEX methods.

- develop nanocontainers (obtained from a mushroom lectine) targeting epithelial cancer cells.

Brief information on available facilites

Present in our group:

  • laboratory for human and animal cultures
  • laboratory for bacterial, yeast and algae cultures
  • laboratory for giant unilamellar vesicles formation
  • animal facilities
  • all the equipement for biochemistry and molecular biology

Present in our institute:

  • fluorescence imaging platform, spectroscopy, flow cytometer
  • zootechnics
  • proteomics 
  • 4 rooms with overhead projector

Willingness to accept/host visiting researchers

Publications

Projects:

  • CERPER
    Project type: National
    Funding: Pierre Fabre Dermo Cosmétique
  • COPOPDT
    Project type: National
    Funding: ANR
  • E-STERIL
    Project type: National
    Funding: Region Midi-Pyrénées
  • ONCOMIR
    Project type: International
    Funding: Europe
  • PIERGEN
    Project type: National
    Funding: ANR and DGA
  • PIRE
    Project type: National
    Funding: Region Midi-Pyrénées
  • TGTS
    Project type: National
    Funding: Regions Midi-Pyrénées et Aquitaine

Members:

  • Elisabeth Bellard
    Email:

    Position: Engineer
  • Sophie Chabot
    Email:

    Position: Post-doc
  • Louise Chopinet
    Email:

    Position: PhD student
  • Mathilde Coustet
    Email:

    Position: Researcher
  • Vincent Ecochard
    Email:

    Position: Researcher
  • Laure Gibot
    Email:

    Position: Post-doc
  • Muriel Golzio
    Email:

    Position: Researcher
  • Laetitia Hellaudais
    Email:

    Position: Technician
  • Caroline Ladurantie
    Email:

    Position: Technician
  • Olivier Martinez
    Email:

    Position: PhD student
  • Laurent Paquereau
    Email:

    Position: Professor
  • Sandrine Pelofy
    Email:

    Position: PhD student
  • Marie-Pierre Rols
    Email:

    Position: Researcher
  • Christelle Rosazza
    Email:

    Position: PhD student
  • Justin Teissié
    Email:

    Position: Researcher

Project Office

Working groups

Steering Committee

Founding members

DC Rapporteurs

Related sites: